Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer
Identifieur interne : 000540 ( Main/Exploration ); précédent : 000539; suivant : 000541Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer
Auteurs : Ludovic Bretin ; Aline Pinon ; Soukaina Bouramtane ; Catherine Ouk ; Laurence Richard ; Marie-Laure Perrin ; Alain Chaunavel ; Claire Carrion ; Frédérique Bregier ; Vincent Sol ; Vincent Chaleix ; David Yannick Leger ; Bertrand LiagreSource :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nanoparticles are able to spontaneously accumulate in solid tumors through an enhanced permeability and retention (EPR) effect due to leaky vasculature, poor lymphatic drainage, and increased vessel permeability. Herein, we proved the added value of nanoparticle vectorization on anticancer efficacy and tumor-targeting by 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (TPPOH). Using 80 nm silica nanoparticles (SNPs) coated with xylan-TPPOH conjugate (TPPOH-X), we first showed very significant phototoxic effects of TPPOH-X SNPs mediated by post-PDT ROS generation and stronger cell uptake in human colorectal cancer cell lines compared to free TPPOH. Additionally, we demonstrated apoptotic cell death induced by TPPOH-X SNPs-PDT and the interest of autophagy inhibition to increase anticancer efficacy. Finally, we highlighted in vivo, without toxicity, elevated anticancer efficacy of TPPOH-X SNPs through improvement of tumor-targeting compared to a free TPPOH protocol. Our work demonstrated for the first time the strong anticancer efficacy of TPPOH in vitro and in vivo and the merit of SNPs vectorization.
Url:
DOI: 10.3390/cancers11101474
PubMed: 31575052
PubMed Central: 6826978
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000459
- to stream Pmc, to step Curation: 000459
- to stream Pmc, to step Checkpoint: 000493
- to stream Ncbi, to step Merge: 000A73
- to stream Ncbi, to step Curation: 000A73
- to stream Ncbi, to step Checkpoint: 000A73
- to stream Main, to step Merge: 000540
- to stream Main, to step Curation: 000540
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer</title><author><name sortKey="Bretin, Ludovic" sort="Bretin, Ludovic" uniqKey="Bretin L" first="Ludovic" last="Bretin">Ludovic Bretin</name><affiliation><nlm:aff id="af1-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>ludovic.bretin@unilim.fr</email> (L.B.);<email>aline.pinon@unilim.fr</email> (A.P.);<email>david.leger@unilim.fr</email> (D.Y.L.)</nlm:aff></affiliation></author><author><name sortKey="Pinon, Aline" sort="Pinon, Aline" uniqKey="Pinon A" first="Aline" last="Pinon">Aline Pinon</name><affiliation><nlm:aff id="af1-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>ludovic.bretin@unilim.fr</email> (L.B.);<email>aline.pinon@unilim.fr</email> (A.P.);<email>david.leger@unilim.fr</email> (D.Y.L.)</nlm:aff></affiliation></author><author><name sortKey="Bouramtane, Soukaina" sort="Bouramtane, Soukaina" uniqKey="Bouramtane S" first="Soukaina" last="Bouramtane">Soukaina Bouramtane</name><affiliation><nlm:aff id="af2-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté des Sciences & Techniques, Université de Limoges 123, Avenue Albert Thomas, 87060 Limoges Cedex, France;<email>soukaina.bouramtane@unilim.fr</email> (S.B.);<email>frederique.bregier@unilim.fr</email> (F.B.);<email>vincent.sol@unilim.fr</email> (V.S.);<email>vincent.chaleix@unilim.fr</email> (V.C.)</nlm:aff></affiliation></author><author><name sortKey="Ouk, Catherine" sort="Ouk, Catherine" uniqKey="Ouk C" first="Catherine" last="Ouk">Catherine Ouk</name><affiliation><nlm:aff id="af3-cancers-11-01474">BISCEm Pôle Cytométrie en flux/Microscopie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>catherine.ouk@unilim.fr</email> (C.O.);<email>claire.carrion@unilim.fr</email> (C.C.)</nlm:aff></affiliation></author><author><name sortKey="Richard, Laurence" sort="Richard, Laurence" uniqKey="Richard L" first="Laurence" last="Richard">Laurence Richard</name><affiliation><nlm:aff id="af4-cancers-11-01474">Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Limoges 2, Avenue Martin Luther King, 87042 Limoges Cedex, France;<email>laurence.richard@unilim.fr</email> (L.R.);<email>alain.chaunavel@chu-limoges.fr</email> (A.C.)</nlm:aff></affiliation></author><author><name sortKey="Perrin, Marie Laure" sort="Perrin, Marie Laure" uniqKey="Perrin M" first="Marie-Laure" last="Perrin">Marie-Laure Perrin</name><affiliation><nlm:aff id="af5-cancers-11-01474">Laboratoire Bio EM XLIM UMR CNRS 7252, Faculté de Médecine, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>marie-laure.perrin@unilim.fr</email></nlm:aff></affiliation></author><author><name sortKey="Chaunavel, Alain" sort="Chaunavel, Alain" uniqKey="Chaunavel A" first="Alain" last="Chaunavel">Alain Chaunavel</name><affiliation><nlm:aff id="af4-cancers-11-01474">Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Limoges 2, Avenue Martin Luther King, 87042 Limoges Cedex, France;<email>laurence.richard@unilim.fr</email> (L.R.);<email>alain.chaunavel@chu-limoges.fr</email> (A.C.)</nlm:aff></affiliation></author><author><name sortKey="Carrion, Claire" sort="Carrion, Claire" uniqKey="Carrion C" first="Claire" last="Carrion">Claire Carrion</name><affiliation><nlm:aff id="af3-cancers-11-01474">BISCEm Pôle Cytométrie en flux/Microscopie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>catherine.ouk@unilim.fr</email> (C.O.);<email>claire.carrion@unilim.fr</email> (C.C.)</nlm:aff></affiliation></author><author><name sortKey="Bregier, Frederique" sort="Bregier, Frederique" uniqKey="Bregier F" first="Frédérique" last="Bregier">Frédérique Bregier</name><affiliation><nlm:aff id="af2-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté des Sciences & Techniques, Université de Limoges 123, Avenue Albert Thomas, 87060 Limoges Cedex, France;<email>soukaina.bouramtane@unilim.fr</email> (S.B.);<email>frederique.bregier@unilim.fr</email> (F.B.);<email>vincent.sol@unilim.fr</email> (V.S.);<email>vincent.chaleix@unilim.fr</email> (V.C.)</nlm:aff></affiliation></author><author><name sortKey="Sol, Vincent" sort="Sol, Vincent" uniqKey="Sol V" first="Vincent" last="Sol">Vincent Sol</name><affiliation><nlm:aff id="af2-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté des Sciences & Techniques, Université de Limoges 123, Avenue Albert Thomas, 87060 Limoges Cedex, France;<email>soukaina.bouramtane@unilim.fr</email> (S.B.);<email>frederique.bregier@unilim.fr</email> (F.B.);<email>vincent.sol@unilim.fr</email> (V.S.);<email>vincent.chaleix@unilim.fr</email> (V.C.)</nlm:aff></affiliation></author><author><name sortKey="Chaleix, Vincent" sort="Chaleix, Vincent" uniqKey="Chaleix V" first="Vincent" last="Chaleix">Vincent Chaleix</name><affiliation><nlm:aff id="af2-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté des Sciences & Techniques, Université de Limoges 123, Avenue Albert Thomas, 87060 Limoges Cedex, France;<email>soukaina.bouramtane@unilim.fr</email> (S.B.);<email>frederique.bregier@unilim.fr</email> (F.B.);<email>vincent.sol@unilim.fr</email> (V.S.);<email>vincent.chaleix@unilim.fr</email> (V.C.)</nlm:aff></affiliation></author><author><name sortKey="Leger, David Yannick" sort="Leger, David Yannick" uniqKey="Leger D" first="David Yannick" last="Leger">David Yannick Leger</name><affiliation><nlm:aff id="af1-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>ludovic.bretin@unilim.fr</email> (L.B.);<email>aline.pinon@unilim.fr</email> (A.P.);<email>david.leger@unilim.fr</email> (D.Y.L.)</nlm:aff></affiliation></author><author><name sortKey="Liagre, Bertrand" sort="Liagre, Bertrand" uniqKey="Liagre B" first="Bertrand" last="Liagre">Bertrand Liagre</name><affiliation><nlm:aff id="af1-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>ludovic.bretin@unilim.fr</email> (L.B.);<email>aline.pinon@unilim.fr</email> (A.P.);<email>david.leger@unilim.fr</email> (D.Y.L.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31575052</idno><idno type="pmc">6826978</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826978</idno><idno type="RBID">PMC:6826978</idno><idno type="doi">10.3390/cancers11101474</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000459</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000459</idno><idno type="wicri:Area/Pmc/Curation">000459</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000459</idno><idno type="wicri:Area/Pmc/Checkpoint">000493</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000493</idno><idno type="wicri:Area/Ncbi/Merge">000A73</idno><idno type="wicri:Area/Ncbi/Curation">000A73</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A73</idno><idno type="wicri:Area/Main/Merge">000540</idno><idno type="wicri:Area/Main/Curation">000540</idno><idno type="wicri:Area/Main/Exploration">000540</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer</title><author><name sortKey="Bretin, Ludovic" sort="Bretin, Ludovic" uniqKey="Bretin L" first="Ludovic" last="Bretin">Ludovic Bretin</name><affiliation><nlm:aff id="af1-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>ludovic.bretin@unilim.fr</email> (L.B.);<email>aline.pinon@unilim.fr</email> (A.P.);<email>david.leger@unilim.fr</email> (D.Y.L.)</nlm:aff></affiliation></author><author><name sortKey="Pinon, Aline" sort="Pinon, Aline" uniqKey="Pinon A" first="Aline" last="Pinon">Aline Pinon</name><affiliation><nlm:aff id="af1-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>ludovic.bretin@unilim.fr</email> (L.B.);<email>aline.pinon@unilim.fr</email> (A.P.);<email>david.leger@unilim.fr</email> (D.Y.L.)</nlm:aff></affiliation></author><author><name sortKey="Bouramtane, Soukaina" sort="Bouramtane, Soukaina" uniqKey="Bouramtane S" first="Soukaina" last="Bouramtane">Soukaina Bouramtane</name><affiliation><nlm:aff id="af2-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté des Sciences & Techniques, Université de Limoges 123, Avenue Albert Thomas, 87060 Limoges Cedex, France;<email>soukaina.bouramtane@unilim.fr</email> (S.B.);<email>frederique.bregier@unilim.fr</email> (F.B.);<email>vincent.sol@unilim.fr</email> (V.S.);<email>vincent.chaleix@unilim.fr</email> (V.C.)</nlm:aff></affiliation></author><author><name sortKey="Ouk, Catherine" sort="Ouk, Catherine" uniqKey="Ouk C" first="Catherine" last="Ouk">Catherine Ouk</name><affiliation><nlm:aff id="af3-cancers-11-01474">BISCEm Pôle Cytométrie en flux/Microscopie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>catherine.ouk@unilim.fr</email> (C.O.);<email>claire.carrion@unilim.fr</email> (C.C.)</nlm:aff></affiliation></author><author><name sortKey="Richard, Laurence" sort="Richard, Laurence" uniqKey="Richard L" first="Laurence" last="Richard">Laurence Richard</name><affiliation><nlm:aff id="af4-cancers-11-01474">Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Limoges 2, Avenue Martin Luther King, 87042 Limoges Cedex, France;<email>laurence.richard@unilim.fr</email> (L.R.);<email>alain.chaunavel@chu-limoges.fr</email> (A.C.)</nlm:aff></affiliation></author><author><name sortKey="Perrin, Marie Laure" sort="Perrin, Marie Laure" uniqKey="Perrin M" first="Marie-Laure" last="Perrin">Marie-Laure Perrin</name><affiliation><nlm:aff id="af5-cancers-11-01474">Laboratoire Bio EM XLIM UMR CNRS 7252, Faculté de Médecine, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>marie-laure.perrin@unilim.fr</email></nlm:aff></affiliation></author><author><name sortKey="Chaunavel, Alain" sort="Chaunavel, Alain" uniqKey="Chaunavel A" first="Alain" last="Chaunavel">Alain Chaunavel</name><affiliation><nlm:aff id="af4-cancers-11-01474">Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Limoges 2, Avenue Martin Luther King, 87042 Limoges Cedex, France;<email>laurence.richard@unilim.fr</email> (L.R.);<email>alain.chaunavel@chu-limoges.fr</email> (A.C.)</nlm:aff></affiliation></author><author><name sortKey="Carrion, Claire" sort="Carrion, Claire" uniqKey="Carrion C" first="Claire" last="Carrion">Claire Carrion</name><affiliation><nlm:aff id="af3-cancers-11-01474">BISCEm Pôle Cytométrie en flux/Microscopie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>catherine.ouk@unilim.fr</email> (C.O.);<email>claire.carrion@unilim.fr</email> (C.C.)</nlm:aff></affiliation></author><author><name sortKey="Bregier, Frederique" sort="Bregier, Frederique" uniqKey="Bregier F" first="Frédérique" last="Bregier">Frédérique Bregier</name><affiliation><nlm:aff id="af2-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté des Sciences & Techniques, Université de Limoges 123, Avenue Albert Thomas, 87060 Limoges Cedex, France;<email>soukaina.bouramtane@unilim.fr</email> (S.B.);<email>frederique.bregier@unilim.fr</email> (F.B.);<email>vincent.sol@unilim.fr</email> (V.S.);<email>vincent.chaleix@unilim.fr</email> (V.C.)</nlm:aff></affiliation></author><author><name sortKey="Sol, Vincent" sort="Sol, Vincent" uniqKey="Sol V" first="Vincent" last="Sol">Vincent Sol</name><affiliation><nlm:aff id="af2-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté des Sciences & Techniques, Université de Limoges 123, Avenue Albert Thomas, 87060 Limoges Cedex, France;<email>soukaina.bouramtane@unilim.fr</email> (S.B.);<email>frederique.bregier@unilim.fr</email> (F.B.);<email>vincent.sol@unilim.fr</email> (V.S.);<email>vincent.chaleix@unilim.fr</email> (V.C.)</nlm:aff></affiliation></author><author><name sortKey="Chaleix, Vincent" sort="Chaleix, Vincent" uniqKey="Chaleix V" first="Vincent" last="Chaleix">Vincent Chaleix</name><affiliation><nlm:aff id="af2-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté des Sciences & Techniques, Université de Limoges 123, Avenue Albert Thomas, 87060 Limoges Cedex, France;<email>soukaina.bouramtane@unilim.fr</email> (S.B.);<email>frederique.bregier@unilim.fr</email> (F.B.);<email>vincent.sol@unilim.fr</email> (V.S.);<email>vincent.chaleix@unilim.fr</email> (V.C.)</nlm:aff></affiliation></author><author><name sortKey="Leger, David Yannick" sort="Leger, David Yannick" uniqKey="Leger D" first="David Yannick" last="Leger">David Yannick Leger</name><affiliation><nlm:aff id="af1-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>ludovic.bretin@unilim.fr</email> (L.B.);<email>aline.pinon@unilim.fr</email> (A.P.);<email>david.leger@unilim.fr</email> (D.Y.L.)</nlm:aff></affiliation></author><author><name sortKey="Liagre, Bertrand" sort="Liagre, Bertrand" uniqKey="Liagre B" first="Bertrand" last="Liagre">Bertrand Liagre</name><affiliation><nlm:aff id="af1-cancers-11-01474">Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, Université de Limoges 2, Rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France;<email>ludovic.bretin@unilim.fr</email> (L.B.);<email>aline.pinon@unilim.fr</email> (A.P.);<email>david.leger@unilim.fr</email> (D.Y.L.)</nlm:aff></affiliation></author></analytic><series><title level="j">Cancers</title><idno type="eISSN">2072-6694</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nanoparticles are able to spontaneously accumulate in solid tumors through an enhanced permeability and retention (EPR) effect due to leaky vasculature, poor lymphatic drainage, and increased vessel permeability. Herein, we proved the added value of nanoparticle vectorization on anticancer efficacy and tumor-targeting by 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (TPPOH). Using 80 nm silica nanoparticles (SNPs) coated with xylan-TPPOH conjugate (TPPOH-X), we first showed very significant phototoxic effects of TPPOH-X SNPs mediated by post-PDT ROS generation and stronger cell uptake in human colorectal cancer cell lines compared to free TPPOH. Additionally, we demonstrated apoptotic cell death induced by TPPOH-X SNPs-PDT and the interest of autophagy inhibition to increase anticancer efficacy. Finally, we highlighted in vivo, without toxicity, elevated anticancer efficacy of TPPOH-X SNPs through improvement of tumor-targeting compared to a free TPPOH protocol. Our work demonstrated for the first time the strong anticancer efficacy of TPPOH in vitro and in vivo and the merit of SNPs vectorization.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Xue, L" uniqKey="Xue L">L. Xue</name></author><author><name sortKey="Williamson, A" uniqKey="Williamson A">A. Williamson</name></author><author><name sortKey="Gaines, S" uniqKey="Gaines S">S. Gaines</name></author><author><name sortKey="Andolfi, C" uniqKey="Andolfi C">C. Andolfi</name></author><author><name sortKey="Paul Olson, T" uniqKey="Paul Olson T">T. Paul-Olson</name></author><author><name sortKey="Neerukonda, A" uniqKey="Neerukonda A">A. Neerukonda</name></author><author><name sortKey="Steinhagen, E" uniqKey="Steinhagen E">E. Steinhagen</name></author><author><name sortKey="Smith, R" uniqKey="Smith R">R. Smith</name></author><author><name sortKey="Cannon, L M" uniqKey="Cannon L">L.M. Cannon</name></author><author><name sortKey="Polite, B" uniqKey="Polite B">B. Polite</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuda, T" uniqKey="Matsuda T">T. Matsuda</name></author><author><name sortKey="Yamashita, K" uniqKey="Yamashita K">K. Yamashita</name></author><author><name sortKey="Hasegawa, H" uniqKey="Hasegawa H">H. Hasegawa</name></author><author><name sortKey="Oshikiri, T" uniqKey="Oshikiri T">T. Oshikiri</name></author><author><name sortKey="Hosono, M" uniqKey="Hosono M">M. Hosono</name></author><author><name sortKey="Higashino, N" uniqKey="Higashino N">N. Higashino</name></author><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name></author><author><name sortKey="Matsuda, Y" uniqKey="Matsuda Y">Y. Matsuda</name></author><author><name sortKey="Kanaji, S" uniqKey="Kanaji S">S. Kanaji</name></author><author><name sortKey="Nakamura, T" uniqKey="Nakamura T">T. Nakamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolpin, B M" uniqKey="Wolpin B">B.M. Wolpin</name></author><author><name sortKey="Mayer, R J" uniqKey="Mayer R">R.J. Mayer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Y T" uniqKey="Lee Y">Y.T. Lee</name></author><author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.J. Tan</name></author><author><name sortKey="Oon, C E" uniqKey="Oon C">C.E. Oon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Jeught, K" uniqKey="Van Der Jeught K">K. Van der Jeught</name></author><author><name sortKey="Xu, H C" uniqKey="Xu H">H.-C. Xu</name></author><author><name sortKey="Li, Y J" uniqKey="Li Y">Y.-J. Li</name></author><author><name sortKey="Lu, X B" uniqKey="Lu X">X.-B. Lu</name></author><author><name sortKey="Ji, G" uniqKey="Ji G">G. Ji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawczyk Krupka, A" uniqKey="Kawczyk Krupka A">A. Kawczyk-Krupka</name></author><author><name sortKey="Bugaj, A M" uniqKey="Bugaj A">A.M. Bugaj</name></author><author><name sortKey="Latos, W" uniqKey="Latos W">W. Latos</name></author><author><name sortKey="Zaremba, K" uniqKey="Zaremba K">K. Zaremba</name></author><author><name sortKey="Wawrzyniec, K" uniqKey="Wawrzyniec K">K. Wawrzyniec</name></author><author><name sortKey="Kucharzewski, M" uniqKey="Kucharzewski M">M. Kucharzewski</name></author><author><name sortKey="Siero, A" uniqKey="Siero A">A. Sieroń</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwiatkowski, S" uniqKey="Kwiatkowski S">S. Kwiatkowski</name></author><author><name sortKey="Knap, B" uniqKey="Knap B">B. Knap</name></author><author><name sortKey="Przystupski, D" uniqKey="Przystupski D">D. Przystupski</name></author><author><name sortKey="Saczko, J" uniqKey="Saczko J">J. Saczko</name></author><author><name sortKey="K Dzierska, E" uniqKey="K Dzierska E">E. Kędzierska</name></author><author><name sortKey="Knap Czop, K" uniqKey="Knap Czop K">K. Knap-Czop</name></author><author><name sortKey="Kotli Ska, J" uniqKey="Kotli Ska J">J. Kotlińska</name></author><author><name sortKey="Michel, O" uniqKey="Michel O">O. Michel</name></author><author><name sortKey="Kotowski, K" uniqKey="Kotowski K">K. Kotowski</name></author><author><name sortKey="Kulbacka, J" uniqKey="Kulbacka J">J. Kulbacka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamblin, M R" uniqKey="Hamblin M">M.R. Hamblin</name></author><author><name sortKey="Mroz, P" uniqKey="Mroz P">P. Mroz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dolmans, D E J G J" uniqKey="Dolmans D">D.E.J.G.J. Dolmans</name></author><author><name sortKey="Fukumura, D" uniqKey="Fukumura D">D. Fukumura</name></author><author><name sortKey="Jain, R K" uniqKey="Jain R">R.K. Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derosa, M C" uniqKey="Derosa M">M.C. DeRosa</name></author><author><name sortKey="Crutchley, R J" uniqKey="Crutchley R">R.J. Crutchley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mroz, P" uniqKey="Mroz P">P. Mroz</name></author><author><name sortKey="Yaroslavsky, A" uniqKey="Yaroslavsky A">A. Yaroslavsky</name></author><author><name sortKey="Kharkwal, G B" uniqKey="Kharkwal G">G.B. Kharkwal</name></author><author><name sortKey="Hamblin, M R" uniqKey="Hamblin M">M.R. Hamblin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plaetzer, K" uniqKey="Plaetzer K">K. Plaetzer</name></author><author><name sortKey="Kiesslich, T" uniqKey="Kiesslich T">T. Kiesslich</name></author><author><name sortKey="Verwanger, T" uniqKey="Verwanger T">T. Verwanger</name></author><author><name sortKey="Krammer, B" uniqKey="Krammer B">B. Krammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abrahamse, H" uniqKey="Abrahamse H">H. Abrahamse</name></author><author><name sortKey="Hamblin, M R" uniqKey="Hamblin M">M.R. Hamblin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saini, R K" uniqKey="Saini R">R.K. Saini</name></author><author><name sortKey="Chouhan, R" uniqKey="Chouhan R">R. Chouhan</name></author><author><name sortKey="Bagri, L P" uniqKey="Bagri L">L.P. Bagri</name></author><author><name sortKey="Bajpai, A K" uniqKey="Bajpai A">A.K. Bajpai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Y Y" uniqKey="Huang Y">Y.Y. Huang</name></author><author><name sortKey="Sharma, S K" uniqKey="Sharma S">S.K. Sharma</name></author><author><name sortKey="Dai, T" uniqKey="Dai T">T. Dai</name></author><author><name sortKey="Chung, H" uniqKey="Chung H">H. Chung</name></author><author><name sortKey="Yaroslavsky, A" uniqKey="Yaroslavsky A">A. Yaroslavsky</name></author><author><name sortKey="Garcia Diaz, M" uniqKey="Garcia Diaz M">M. Garcia-Diaz</name></author><author><name sortKey="Chang, J" uniqKey="Chang J">J. Chang</name></author><author><name sortKey="Chiang, L Y" uniqKey="Chiang L">L.Y. Chiang</name></author><author><name sortKey="Hamblin, M R" uniqKey="Hamblin M">M.R. Hamblin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iyer, A K" uniqKey="Iyer A">A.K. Iyer</name></author><author><name sortKey="Khaled, G" uniqKey="Khaled G">G. Khaled</name></author><author><name sortKey="Fang, J" uniqKey="Fang J">J. Fang</name></author><author><name sortKey="Maeda, H" uniqKey="Maeda H">H. Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Liang, X" uniqKey="Liang X">X. Liang</name></author><author><name sortKey="Dai, Z" uniqKey="Dai Z">Z. Dai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debele, T A" uniqKey="Debele T">T.A. Debele</name></author><author><name sortKey="Peng, S" uniqKey="Peng S">S. Peng</name></author><author><name sortKey="Tsai, H C" uniqKey="Tsai H">H.-C. Tsai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author><author><name sortKey="Wu, M" uniqKey="Wu M">M. Wu</name></author><author><name sortKey="Xiaojun Zhao, J" uniqKey="Xiaojun Zhao J">J. Xiaojun Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Couleaud, P" uniqKey="Couleaud P">P. Couleaud</name></author><author><name sortKey="Morosini, V" uniqKey="Morosini V">V. Morosini</name></author><author><name sortKey="Frochot, C" uniqKey="Frochot C">C. Frochot</name></author><author><name sortKey="Richeter, S" uniqKey="Richeter S">S. Richeter</name></author><author><name sortKey="Raehm, L" uniqKey="Raehm L">L. Raehm</name></author><author><name sortKey="Durand, J O" uniqKey="Durand J">J.-O. Durand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J. Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemarchand, C" uniqKey="Lemarchand C">C. Lemarchand</name></author><author><name sortKey="Gref, R" uniqKey="Gref R">R. Gref</name></author><author><name sortKey="Couvreur, P" uniqKey="Couvreur P">P. Couvreur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gref, R" uniqKey="Gref R">R. Gref</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Owens, D E" uniqKey="Owens D">D.E. Owens</name></author><author><name sortKey="Peppas, N A" uniqKey="Peppas N">N.A. Peppas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shrotri, A" uniqKey="Shrotri A">A. Shrotri</name></author><author><name sortKey="Kobayashi, H" uniqKey="Kobayashi H">H. Kobayashi</name></author><author><name sortKey="Fukuoka, A" uniqKey="Fukuoka A">A. Fukuoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, J" uniqKey="Ma J">J. Ma</name></author><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name></author><author><name sortKey="Zhong, L" uniqKey="Zhong L">L. Zhong</name></author><author><name sortKey="Du, F" uniqKey="Du F">F. Du</name></author><author><name sortKey="Tan, J" uniqKey="Tan J">J. Tan</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name></author><author><name sortKey="Peng, X" uniqKey="Peng X">X. Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daus, S" uniqKey="Daus S">S. Daus</name></author><author><name sortKey="Heinze, T" uniqKey="Heinze T">T. Heinze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouramtane, S" uniqKey="Bouramtane S">S. Bouramtane</name></author><author><name sortKey="Bretin, L" uniqKey="Bretin L">L. Bretin</name></author><author><name sortKey="Pinon, A" uniqKey="Pinon A">A. Pinon</name></author><author><name sortKey="Leger, D" uniqKey="Leger D">D. Leger</name></author><author><name sortKey="Liagre, B" uniqKey="Liagre B">B. Liagre</name></author><author><name sortKey="Richard, L" uniqKey="Richard L">L. Richard</name></author><author><name sortKey="Bregier, F" uniqKey="Bregier F">F. Brégier</name></author><author><name sortKey="Sol, V" uniqKey="Sol V">V. Sol</name></author><author><name sortKey="Chaleix, V" uniqKey="Chaleix V">V. Chaleix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, K" uniqKey="Lai K">K. Lai</name></author><author><name sortKey="Killingsworth, M C" uniqKey="Killingsworth M">M.C. Killingsworth</name></author><author><name sortKey="Lee, C S" uniqKey="Lee C">C.S. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duan, X" uniqKey="Duan X">X. Duan</name></author><author><name sortKey="Chen, B" uniqKey="Chen B">B. Chen</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y. Cui</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name></author><author><name sortKey="Wu, C" uniqKey="Wu C">C. Wu</name></author><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name></author><author><name sortKey="Wen, Y" uniqKey="Wen Y">Y. Wen</name></author><author><name sortKey="Miao, X" uniqKey="Miao X">X. Miao</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author><author><name sortKey="Xiong, L" uniqKey="Xiong L">L. Xiong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hackbarth, S" uniqKey="Hackbarth S">S. Hackbarth</name></author><author><name sortKey="Horneffer, V" uniqKey="Horneffer V">V. Horneffer</name></author><author><name sortKey="Wiehe, A" uniqKey="Wiehe A">A. Wiehe</name></author><author><name sortKey="Hillenkamp, F" uniqKey="Hillenkamp F">F. Hillenkamp</name></author><author><name sortKey="Roder, B" uniqKey="Roder B">B. Röder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Jang, W D" uniqKey="Jang W">W.D. Jang</name></author><author><name sortKey="Nishiyama, N" uniqKey="Nishiyama N">N. Nishiyama</name></author><author><name sortKey="Kishimura, A" uniqKey="Kishimura A">A. Kishimura</name></author><author><name sortKey="Kawauchi, S" uniqKey="Kawauchi S">S. Kawauchi</name></author><author><name sortKey="Morimoto, Y" uniqKey="Morimoto Y">Y. Morimoto</name></author><author><name sortKey="Miake, S" uniqKey="Miake S">S. Miake</name></author><author><name sortKey="Yamashita, T" uniqKey="Yamashita T">T. Yamashita</name></author><author><name sortKey="Kikuchi, M" uniqKey="Kikuchi M">M. Kikuchi</name></author><author><name sortKey="Aida, T" uniqKey="Aida T">T. Aida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, I" uniqKey="Roy I">I. Roy</name></author><author><name sortKey="Ohulchanskyy, T Y" uniqKey="Ohulchanskyy T">T.Y. Ohulchanskyy</name></author><author><name sortKey="Pudavar, H E" uniqKey="Pudavar H">H.E. Pudavar</name></author><author><name sortKey="Bergey, E J" uniqKey="Bergey E">E.J. Bergey</name></author><author><name sortKey="Oseroff, A R" uniqKey="Oseroff A">A.R. Oseroff</name></author><author><name sortKey="Morgan, J" uniqKey="Morgan J">J. Morgan</name></author><author><name sortKey="Dougherty, T J" uniqKey="Dougherty T">T.J. Dougherty</name></author><author><name sortKey="Prasad, P N" uniqKey="Prasad P">P.N. Prasad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Secret, E" uniqKey="Secret E">E. Secret</name></author><author><name sortKey="Maynadier, M" uniqKey="Maynadier M">M. Maynadier</name></author><author><name sortKey="Gallud, A" uniqKey="Gallud A">A. Gallud</name></author><author><name sortKey="Gary Bobo, M" uniqKey="Gary Bobo M">M. Gary-Bobo</name></author><author><name sortKey="Chaix, A" uniqKey="Chaix A">A. Chaix</name></author><author><name sortKey="Belamie, E" uniqKey="Belamie E">E. Belamie</name></author><author><name sortKey="Maillard, P" uniqKey="Maillard P">P. Maillard</name></author><author><name sortKey="Sailor, M J" uniqKey="Sailor M">M.J. Sailor</name></author><author><name sortKey="Garcia, M" uniqKey="Garcia M">M. Garcia</name></author><author><name sortKey="Durand, J O" uniqKey="Durand J">J.O. Durand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Youssef, Z" uniqKey="Youssef Z">Z. Youssef</name></author><author><name sortKey="Jouan Hureaux, V" uniqKey="Jouan Hureaux V">V. Jouan-Hureaux</name></author><author><name sortKey="Colombeau, L" uniqKey="Colombeau L">L. Colombeau</name></author><author><name sortKey="Arnoux, P" uniqKey="Arnoux P">P. Arnoux</name></author><author><name sortKey="Moussaron, A" uniqKey="Moussaron A">A. Moussaron</name></author><author><name sortKey="Baros, F" uniqKey="Baros F">F. Baros</name></author><author><name sortKey="Toufaily, J" uniqKey="Toufaily J">J. Toufaily</name></author><author><name sortKey="Hamieh, T" uniqKey="Hamieh T">T. Hamieh</name></author><author><name sortKey="Roques Carmes, T" uniqKey="Roques Carmes T">T. Roques-Carmes</name></author><author><name sortKey="Frochot, C" uniqKey="Frochot C">C. Frochot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bharathiraja, S" uniqKey="Bharathiraja S">S. Bharathiraja</name></author><author><name sortKey="Moorthy, M S" uniqKey="Moorthy M">M.S. Moorthy</name></author><author><name sortKey="Manivasagan, P" uniqKey="Manivasagan P">P. Manivasagan</name></author><author><name sortKey="Seo, H" uniqKey="Seo H">H. Seo</name></author><author><name sortKey="Lee, K D" uniqKey="Lee K">K.D. Lee</name></author><author><name sortKey="Oh, J" uniqKey="Oh J">J. Oh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brezaniova, I" uniqKey="Brezaniova I">I. Brezániová</name></author><author><name sortKey="Zaruba, K" uniqKey="Zaruba K">K. Záruba</name></author><author><name sortKey="Kralova, J" uniqKey="Kralova J">J. Králová</name></author><author><name sortKey="Adamkova, H" uniqKey="Adamkova H">H. Adámková</name></author><author><name sortKey="Ulbrich, P" uniqKey="Ulbrich P">P. Ulbrich</name></author><author><name sortKey="Pou Kova, P" uniqKey="Pou Kova P">P. Poučková</name></author><author><name sortKey="Hrub, M" uniqKey="Hrub M">M. Hrubý</name></author><author><name sortKey="St Panek, P" uniqKey="St Panek P">P. Štěpánek</name></author><author><name sortKey="Kral, V" uniqKey="Kral V">V. Král</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simon, V" uniqKey="Simon V">V. Simon</name></author><author><name sortKey="Devaux, C" uniqKey="Devaux C">C. Devaux</name></author><author><name sortKey="Darmon, A" uniqKey="Darmon A">A. Darmon</name></author><author><name sortKey="Donnet, T" uniqKey="Donnet T">T. Donnet</name></author><author><name sortKey="Thienot, E" uniqKey="Thienot E">E. Thiénot</name></author><author><name sortKey="Germain, M" uniqKey="Germain M">M. Germain</name></author><author><name sortKey="Honnorat, J" uniqKey="Honnorat J">J. Honnorat</name></author><author><name sortKey="Duval, A" uniqKey="Duval A">A. Duval</name></author><author><name sortKey="Pottier, A" uniqKey="Pottier A">A. Pottier</name></author><author><name sortKey="Borghi, E" uniqKey="Borghi E">E. Borghi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, V" uniqKey="Kumar V">V. Kumar</name></author><author><name sortKey="Kumar, B" uniqKey="Kumar B">B. Kumar</name></author><author><name sortKey="Deeba, F" uniqKey="Deeba F">F. Deeba</name></author><author><name sortKey="Bano, S" uniqKey="Bano S">S. Bano</name></author><author><name sortKey="Kulshreshtha, A" uniqKey="Kulshreshtha A">A. Kulshreshtha</name></author><author><name sortKey="Gopinath, P" uniqKey="Gopinath P">P. Gopinath</name></author><author><name sortKey="Negi, Y S" uniqKey="Negi Y">Y.S. Negi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sauraj Kumar, S U" uniqKey="Sauraj Kumar S">S.U. Sauraj Kumar</name></author><author><name sortKey="Kumar, V" uniqKey="Kumar V">V. Kumar</name></author><author><name sortKey="Priyadarshi, R" uniqKey="Priyadarshi R">R. Priyadarshi</name></author><author><name sortKey="Gopinath, P" uniqKey="Gopinath P">P. Gopinath</name></author><author><name sortKey="Negi, Y S" uniqKey="Negi Y">Y.S. Negi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J. Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sergent, J A" uniqKey="Sergent J">J.-A. Sergent</name></author><author><name sortKey="Paget, V" uniqKey="Paget V">V. Paget</name></author><author><name sortKey="Chevillard, S" uniqKey="Chevillard S">S. Chevillard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, M" uniqKey="Cho M">M. Cho</name></author><author><name sortKey="Cho, W S" uniqKey="Cho W">W.S. Cho</name></author><author><name sortKey="Choi, M" uniqKey="Choi M">M. Choi</name></author><author><name sortKey="Kim, S J" uniqKey="Kim S">S.J. Kim</name></author><author><name sortKey="Han, B S" uniqKey="Han B">B.S. Han</name></author><author><name sortKey="Kim, S H" uniqKey="Kim S">S.H. Kim</name></author><author><name sortKey="Kim, H O" uniqKey="Kim H">H.O. Kim</name></author><author><name sortKey="Sheen, Y Y" uniqKey="Sheen Y">Y.Y. Sheen</name></author><author><name sortKey="Jeong, J" uniqKey="Jeong J">J. Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, R" uniqKey="Kumar R">R. Kumar</name></author><author><name sortKey="Roy, I" uniqKey="Roy I">I. Roy</name></author><author><name sortKey="Ohulchanskky, T Y" uniqKey="Ohulchanskky T">T.Y. Ohulchanskky</name></author><author><name sortKey="Vathy, L A" uniqKey="Vathy L">L.A. Vathy</name></author><author><name sortKey="Bergey, E J" uniqKey="Bergey E">E.J. Bergey</name></author><author><name sortKey="Sajjad, M" uniqKey="Sajjad M">M. Sajjad</name></author><author><name sortKey="Prasad, P N" uniqKey="Prasad P">P.N. Prasad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, W T" uniqKey="Chan W">W.T. Chan</name></author><author><name sortKey="Liu, C C" uniqKey="Liu C">C.C. Liu</name></author><author><name sortKey="Chiau, J S C" uniqKey="Chiau J">J.S.C. Chiau</name></author><author><name sortKey="Tsai, S T" uniqKey="Tsai S">S.T. Tsai</name></author><author><name sortKey="Liang, C K" uniqKey="Liang C">C.K. Liang</name></author><author><name sortKey="Cheng, M L" uniqKey="Cheng M">M.L. Cheng</name></author><author><name sortKey="Lee, H C" uniqKey="Lee H">H.C. Lee</name></author><author><name sortKey="Yeung, C Y" uniqKey="Yeung C">C.Y. Yeung</name></author><author><name sortKey="Hou, S Y" uniqKey="Hou S">S.Y. Hou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name></author><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Teng, X" uniqKey="Teng X">X. Teng</name></author><author><name sortKey="Huang, X" uniqKey="Huang X">X. Huang</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Chen, D" uniqKey="Chen D">D. Chen</name></author><author><name sortKey="Ren, J" uniqKey="Ren J">J. Ren</name></author><author><name sortKey="He, J" uniqKey="He J">J. He</name></author><author><name sortKey="Tang, F" uniqKey="Tang F">F. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, C N" uniqKey="Zhou C">C.N. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elmore, S" uniqKey="Elmore S">S. Elmore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Zhu, F" uniqKey="Zhu F">F. Zhu</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J. Jiang</name></author><author><name sortKey="Sun, C" uniqKey="Sun C">C. Sun</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Shen, M" uniqKey="Shen M">M. Shen</name></author><author><name sortKey="Tian, R" uniqKey="Tian R">R. Tian</name></author><author><name sortKey="Shi, C" uniqKey="Shi C">C. Shi</name></author><author><name sortKey="Xu, M" uniqKey="Xu M">M. Xu</name></author><author><name sortKey="Peng, F" uniqKey="Peng F">F. Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skulachev, V P" uniqKey="Skulachev V">V.P. Skulachev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costa, L D" uniqKey="Costa L">L.D. Costa</name></author><author><name sortKey="De Silva, J A" uniqKey="De Silva J">J.A. de Silva</name></author><author><name sortKey="Fonseca, S M" uniqKey="Fonseca S">S.M. Fonseca</name></author><author><name sortKey="Arranja, C T" uniqKey="Arranja C">C.T. Arranja</name></author><author><name sortKey="Urbano, A M" uniqKey="Urbano A">A.M. Urbano</name></author><author><name sortKey="Sobral, A J F N" uniqKey="Sobral A">A.J.F.N. Sobral</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baldea, I" uniqKey="Baldea I">I. Baldea</name></author><author><name sortKey="Olteanu, D E" uniqKey="Olteanu D">D.E. Olteanu</name></author><author><name sortKey="Bolfa, P" uniqKey="Bolfa P">P. Bolfa</name></author><author><name sortKey="Ion, R M" uniqKey="Ion R">R.M. Ion</name></author><author><name sortKey="Decea, N" uniqKey="Decea N">N. Decea</name></author><author><name sortKey="Cenariu, M" uniqKey="Cenariu M">M. Cenariu</name></author><author><name sortKey="Banciu, M" uniqKey="Banciu M">M. Banciu</name></author><author><name sortKey="Sesarman, A V" uniqKey="Sesarman A">A.V. Sesarman</name></author><author><name sortKey="Filip, A G" uniqKey="Filip A">A.G. Filip</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liao, P Y" uniqKey="Liao P">P.Y. Liao</name></author><author><name sortKey="Gao, Y H" uniqKey="Gao Y">Y.H. Gao</name></author><author><name sortKey="Wang, X R" uniqKey="Wang X">X.R. Wang</name></author><author><name sortKey="Bao, L L" uniqKey="Bao L">L.L. Bao</name></author><author><name sortKey="Bian, J" uniqKey="Bian J">J. Bian</name></author><author><name sortKey="Hu, T S" uniqKey="Hu T">T.S. Hu</name></author><author><name sortKey="Zheng, M Z" uniqKey="Zheng M">M.Z. Zheng</name></author><author><name sortKey="Yan, Y J" uniqKey="Yan Y">Y.J. Yan</name></author><author><name sortKey="Chen, Z L" uniqKey="Chen Z">Z.L. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roby, A" uniqKey="Roby A">A. Roby</name></author><author><name sortKey="Erdogan, S" uniqKey="Erdogan S">S. Erdogan</name></author><author><name sortKey="Torchilin, V P" uniqKey="Torchilin V">V.P. Torchilin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, M" uniqKey="Wu M">M. Wu</name></author><author><name sortKey="Wu, L" uniqKey="Wu L">L. Wu</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name></author><author><name sortKey="Lan, S" uniqKey="Lan S">S. Lan</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X. Lin</name></author><author><name sortKey="Liu, G" uniqKey="Liu G">G. Liu</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janku, F" uniqKey="Janku F">F. Janku</name></author><author><name sortKey="Mcconkey, D J" uniqKey="Mcconkey D">D.J. McConkey</name></author><author><name sortKey="Hong, D S" uniqKey="Hong D">D.S. Hong</name></author><author><name sortKey="Kurzrock, R" uniqKey="Kurzrock R">R. Kurzrock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xue, Q" uniqKey="Xue Q">Q. Xue</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K. Zhang</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiong, L" uniqKey="Xiong L">L. Xiong</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name></author><author><name sortKey="Ouyang, G" uniqKey="Ouyang G">G. Ouyang</name></author><author><name sortKey="Lin, L" uniqKey="Lin L">L. Lin</name></author><author><name sortKey="Huang, H" uniqKey="Huang H">H. Huang</name></author><author><name sortKey="Kang, H" uniqKey="Kang H">H. Kang</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name></author><author><name sortKey="Miao, X" uniqKey="Miao X">X. Miao</name></author><author><name sortKey="Wen, Y" uniqKey="Wen Y">Y. Wen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, M F" uniqKey="Wei M">M.F. Wei</name></author><author><name sortKey="Chen, M W" uniqKey="Chen M">M.W. Chen</name></author><author><name sortKey="Chen, K C" uniqKey="Chen K">K.C. Chen</name></author><author><name sortKey="Lou, P J" uniqKey="Lou P">P.J. Lou</name></author><author><name sortKey="Lin, S Y F" uniqKey="Lin S">S.Y.F. Lin</name></author><author><name sortKey="Hung, S C" uniqKey="Hung S">S.C. Hung</name></author><author><name sortKey="Hsiao, M" uniqKey="Hsiao M">M. Hsiao</name></author><author><name sortKey="Yao, C J" uniqKey="Yao C">C.J. Yao</name></author><author><name sortKey="Shieh, M J" uniqKey="Shieh M">M.J. Shieh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tu, P" uniqKey="Tu P">P. Tu</name></author><author><name sortKey="Huang, Q" uniqKey="Huang Q">Q. Huang</name></author><author><name sortKey="Ou, Y" uniqKey="Ou Y">Y. Ou</name></author><author><name sortKey="Du, X" uniqKey="Du X">X. Du</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Tao, Y" uniqKey="Tao Y">Y. Tao</name></author><author><name sortKey="Yin, H" uniqKey="Yin H">H. Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, J" uniqKey="Zhu J">J. Zhu</name></author><author><name sortKey="Tian, S" uniqKey="Tian S">S. Tian</name></author><author><name sortKey="Li, K T" uniqKey="Li K">K.T. Li</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name></author><author><name sortKey="Lin, H D" uniqKey="Lin H">H.D. Lin</name></author><author><name sortKey="Yu, L H" uniqKey="Yu L">L.H. Yu</name></author><author><name sortKey="Bai, D Q" uniqKey="Bai D">D.Q. Bai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lepage, C" uniqKey="Lepage C">C. Lepage</name></author><author><name sortKey="Leger, D Y" uniqKey="Leger D">D.Y. Léger</name></author><author><name sortKey="Bertrand, J" uniqKey="Bertrand J">J. Bertrand</name></author><author><name sortKey="Martin, F" uniqKey="Martin F">F. Martin</name></author><author><name sortKey="Beneytout, J L" uniqKey="Beneytout J">J.L. Beneytout</name></author><author><name sortKey="Liagre, B" uniqKey="Liagre B">B. Liagre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, J" uniqKey="Lu J">J. Lu</name></author><author><name sortKey="Liong, M" uniqKey="Liong M">M. Liong</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Zink, J I" uniqKey="Zink J">J.I. Zink</name></author><author><name sortKey="Tamanoi, F" uniqKey="Tamanoi F">F. Tamanoi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Hou, N" uniqKey="Hou N">N. Hou</name></author><author><name sortKey="Faried, A" uniqKey="Faried A">A. Faried</name></author><author><name sortKey="Tsutsumi, S" uniqKey="Tsutsumi S">S. Tsutsumi</name></author><author><name sortKey="Kuwano, H" uniqKey="Kuwano H">H. Kuwano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fidanzi Dugas, C" uniqKey="Fidanzi Dugas C">C. Fidanzi-Dugas</name></author><author><name sortKey="Liagre, B" uniqKey="Liagre B">B. Liagre</name></author><author><name sortKey="Chemin, G" uniqKey="Chemin G">G. Chemin</name></author><author><name sortKey="Perraud, A" uniqKey="Perraud A">A. Perraud</name></author><author><name sortKey="Carrion, C" uniqKey="Carrion C">C. Carrion</name></author><author><name sortKey="Couquet, C Y" uniqKey="Couquet C">C.Y. Couquet</name></author><author><name sortKey="Granet, R" uniqKey="Granet R">R. Granet</name></author><author><name sortKey="Sol, V" uniqKey="Sol V">V. Sol</name></author><author><name sortKey="Leger, D Y" uniqKey="Leger D">D.Y. Léger</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bouramtane, Soukaina" sort="Bouramtane, Soukaina" uniqKey="Bouramtane S" first="Soukaina" last="Bouramtane">Soukaina Bouramtane</name><name sortKey="Bregier, Frederique" sort="Bregier, Frederique" uniqKey="Bregier F" first="Frédérique" last="Bregier">Frédérique Bregier</name><name sortKey="Bretin, Ludovic" sort="Bretin, Ludovic" uniqKey="Bretin L" first="Ludovic" last="Bretin">Ludovic Bretin</name><name sortKey="Carrion, Claire" sort="Carrion, Claire" uniqKey="Carrion C" first="Claire" last="Carrion">Claire Carrion</name><name sortKey="Chaleix, Vincent" sort="Chaleix, Vincent" uniqKey="Chaleix V" first="Vincent" last="Chaleix">Vincent Chaleix</name><name sortKey="Chaunavel, Alain" sort="Chaunavel, Alain" uniqKey="Chaunavel A" first="Alain" last="Chaunavel">Alain Chaunavel</name><name sortKey="Leger, David Yannick" sort="Leger, David Yannick" uniqKey="Leger D" first="David Yannick" last="Leger">David Yannick Leger</name><name sortKey="Liagre, Bertrand" sort="Liagre, Bertrand" uniqKey="Liagre B" first="Bertrand" last="Liagre">Bertrand Liagre</name><name sortKey="Ouk, Catherine" sort="Ouk, Catherine" uniqKey="Ouk C" first="Catherine" last="Ouk">Catherine Ouk</name><name sortKey="Perrin, Marie Laure" sort="Perrin, Marie Laure" uniqKey="Perrin M" first="Marie-Laure" last="Perrin">Marie-Laure Perrin</name><name sortKey="Pinon, Aline" sort="Pinon, Aline" uniqKey="Pinon A" first="Aline" last="Pinon">Aline Pinon</name><name sortKey="Richard, Laurence" sort="Richard, Laurence" uniqKey="Richard L" first="Laurence" last="Richard">Laurence Richard</name><name sortKey="Sol, Vincent" sort="Sol, Vincent" uniqKey="Sol V" first="Vincent" last="Sol">Vincent Sol</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000540 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000540 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6826978
|texte= Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31575052" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |